rs2853098
Variant in the TBK1 gene (TANK Binding Kinase 1)
rs2853098 is a single nucleotide polymorphism (SNP) in the TBK1 gene, involved in interferon signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2853098 variant?
rs2853098 is a SNP (single nucleotide polymorphism) in the TBK1 (TANK Binding Kinase 1) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. TBK1 is a non-canonical IκB kinase that phosphorylates IRF3/IRF7 downstream of cGAS-STING and RLR pathways, driving type I interferon production. It is also involved in autophagy receptor phosphorylation.
Biological role and pathway
This variant sits within the TBK1 gene, which is involved in the interferon signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2853098 and Long COVID / ME-CFS research
SARS-CoV-2 non-structural proteins directly inhibit TBK1 to evade interferon induction. TBK1 variants may affect initial viral clearance efficiency. TBK1 also links antiviral signaling to autophagy, relevant to the autophagy dysfunction proposed in ME/CFS.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TBK1
rs2853098 is one of 3 known variants in the TBK1 gene. To understand the full biological context of this variant, explore the parent gene page.
View TBK1 gene page →Conditions studied in relation to rs2853098
Research into TBK1 variants including rs2853098 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TBK1 and the rs2853098 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TBK1 gene
The following variants in TBK1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2853098 variant in the TBK1 gene?
rs2853098 is a single nucleotide polymorphism (SNP) located in the TBK1 (TANK Binding Kinase 1) gene, which is involved in interferon signaling. TBK1 is a non-canonical IκB kinase that phosphorylates IRF3/IRF7 downstream of cGAS-STING and RLR pathways, driving type I interferon production. It is also involved in autophagy receptor phosphorylation.
How may the rs2853098 variant relate to Long COVID or ME/CFS?
SARS-CoV-2 non-structural proteins directly inhibit TBK1 to evade interferon induction. TBK1 variants may affect initial viral clearance efficiency. TBK1 also links antiviral signaling to autophagy, relevant to the autophagy dysfunction proposed in ME/CFS.
Can a consumer DNA test detect the rs2853098 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2853098 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TBK1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33472049
- [2]Cell
- [3]Nature Immunology