rs7285167

What is the rs7285167 variant?

rs7285167 is a SNP (single nucleotide polymorphism) in the TBK1 (TANK Binding Kinase 1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. TBK1 is a serine/threonine kinase downstream of STING, RIG-I/MDA5, and TLRs that phosphorylates and activates IRF3 to induce type I interferons.

Biological role and pathway

This variant sits within the TBK1 gene, which is involved in the innate immune signaling / type I interferon induction pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TBK1

rs7285167 is one of 3 known variants in the TBK1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs7285167

Research into TBK1 variants including rs7285167 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TBK1 and the rs7285167 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the TBK1 gene

The following variants in TBK1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions