rs11613919
Variant in the TFPI gene (Tissue Factor Pathway Inhibitor)
rs11613919 is a single nucleotide polymorphism (SNP) in the TFPI gene, involved in coagulation initiation inhibition. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11613919 variant?
rs11613919 is a SNP (single nucleotide polymorphism) in the TFPI (Tissue Factor Pathway Inhibitor) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. TFPI is the primary physiological inhibitor of the extrinsic coagulation pathway, inhibiting factor Xa and the TF-FVIIa complex. It is produced by endothelial cells and circulates bound to lipoproteins.
Biological role and pathway
This variant sits within the TFPI gene, which is involved in the coagulation initiation inhibition pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11613919 and Long COVID / ME-CFS research
TFPI controls coagulation initiation through TF-FVIIa. In COVID-19, TF expression is elevated and TFPI may be insufficient to prevent fibrin deposition. TFPI variants affecting its anticoagulant potency may influence microthrombi formation relevant to Long COVID vascular complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TFPI
rs11613919 is one of 3 known variants in the TFPI gene. To understand the full biological context of this variant, explore the parent gene page.
View TFPI gene page →Conditions studied in relation to rs11613919
Research into TFPI variants including rs11613919 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TFPI and the rs11613919 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TFPI gene
The following variants in TFPI are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11613919 variant in the TFPI gene?
rs11613919 is a single nucleotide polymorphism (SNP) located in the TFPI (Tissue Factor Pathway Inhibitor) gene, which is involved in coagulation initiation inhibition. TFPI is the primary physiological inhibitor of the extrinsic coagulation pathway, inhibiting factor Xa and the TF-FVIIa complex. It is produced by endothelial cells and circulates bound to lipoproteins.
How may the rs11613919 variant relate to Long COVID or ME/CFS?
TFPI controls coagulation initiation through TF-FVIIa. In COVID-19, TF expression is elevated and TFPI may be insufficient to prevent fibrin deposition. TFPI variants affecting its anticoagulant potency may influence microthrombi formation relevant to Long COVID vascular complications.
Can a consumer DNA test detect the rs11613919 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11613919 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TFPI and its variants. This is not an exhaustive literature review.
- [1]PMID: 27516441
- [2]Blood
- [3]Arteriosclerosis Thrombosis and Vascular Biology