rs8176592
Variant in the TFPI gene (Tissue Factor Pathway Inhibitor)
rs8176592 is a single nucleotide polymorphism (SNP) in the TFPI gene, involved in tissue factor anticoagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs8176592 variant?
rs8176592 is a SNP (single nucleotide polymorphism) in the TFPI (Tissue Factor Pathway Inhibitor) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. TFPI encodes the primary inhibitor of the tissue factor-factor VIIa complex, preventing initiation of extrinsic coagulation.
Biological role and pathway
This variant sits within the TFPI gene, which is involved in the tissue factor anticoagulation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs8176592 and Long COVID / ME-CFS research
TFPI controls tissue factor-mediated coagulation activation; variants may affect thrombotic risk in COVID-19-associated coagulopathy and Long COVID vascular complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TFPI
rs8176592 is one of 3 known variants in the TFPI gene. To understand the full biological context of this variant, explore the parent gene page.
View TFPI gene page →Conditions studied in relation to rs8176592
Research into TFPI variants including rs8176592 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TFPI and the rs8176592 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TFPI gene
The following variants in TFPI are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs8176592 variant in the TFPI gene?
rs8176592 is a single nucleotide polymorphism (SNP) located in the TFPI (Tissue Factor Pathway Inhibitor) gene, which is involved in tissue factor anticoagulation. TFPI encodes the primary inhibitor of the tissue factor-factor VIIa complex, preventing initiation of extrinsic coagulation.
How may the rs8176592 variant relate to Long COVID or ME/CFS?
TFPI controls tissue factor-mediated coagulation activation; variants may affect thrombotic risk in COVID-19-associated coagulopathy and Long COVID vascular complications.
Can a consumer DNA test detect the rs8176592 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs8176592 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TFPI and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Thrombosis and Haemostasis