rs1967148
Variant in the TMPRSS11D gene (Transmembrane Serine Protease 11D (HAT))
rs1967148 is a single nucleotide polymorphism (SNP) in the TMPRSS11D gene, involved in airway epithelial serine protease. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1967148 variant?
rs1967148 is a SNP (single nucleotide polymorphism) in the TMPRSS11D (Transmembrane Serine Protease 11D (HAT)) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. TMPRSS11D encodes human airway trypsin-like protease (HAT), expressed in the trachea and bronchi, which can activate respiratory viruses.
Biological role and pathway
This variant sits within the TMPRSS11D gene, which is involved in the airway epithelial serine protease pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1967148 and Long COVID / ME-CFS research
Airway serine proteases can prime SARS-CoV-2 spike for membrane fusion; TMPRSS11D variants may affect viral entry efficiency in airway cells relevant to Long COVID respiratory involvement.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TMPRSS11D
rs1967148 is one of 1 known variant in the TMPRSS11D gene. To understand the full biological context of this variant, explore the parent gene page.
View TMPRSS11D gene page →Conditions studied in relation to rs1967148
Research into TMPRSS11D variants including rs1967148 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TMPRSS11D and the rs1967148 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1967148 variant in the TMPRSS11D gene?
rs1967148 is a single nucleotide polymorphism (SNP) located in the TMPRSS11D (Transmembrane Serine Protease 11D (HAT)) gene, which is involved in airway epithelial serine protease. TMPRSS11D encodes human airway trypsin-like protease (HAT), expressed in the trachea and bronchi, which can activate respiratory viruses.
How may the rs1967148 variant relate to Long COVID or ME/CFS?
Airway serine proteases can prime SARS-CoV-2 spike for membrane fusion; TMPRSS11D variants may affect viral entry efficiency in airway cells relevant to Long COVID respiratory involvement.
Can a consumer DNA test detect the rs1967148 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1967148 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TMPRSS11D and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Nature Genetics
- [3]Cell