rs3135945
Variant in the TREX1 gene (Three Prime Repair Exonuclease 1)
rs3135945 is a single nucleotide polymorphism (SNP) in the TREX1 gene, involved in cytosolic DNA clearance / cGAS-STING regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3135945 variant?
rs3135945 is a SNP (single nucleotide polymorphism) in the TREX1 (Three Prime Repair Exonuclease 1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. TREX1 is a cytosolic 3'-to-5' exonuclease that degrades cytosolic DNA, preventing spontaneous activation of the cGAS-STING pathway.
Biological role and pathway
This variant sits within the TREX1 gene, which is involved in the cytosolic DNA clearance / cGAS-STING regulation pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3135945 and Long COVID / ME-CFS research
TREX1 loss-of-function mutations cause Aicardi-Goutières syndrome (a monogenic interferonopathy); common variants may affect basal cGAS-STING activation and contribute to the chronic interferon signature in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TREX1
rs3135945 is one of 3 known variants in the TREX1 gene. To understand the full biological context of this variant, explore the parent gene page.
View TREX1 gene page →Conditions studied in relation to rs3135945
Research into TREX1 variants including rs3135945 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TREX1 and the rs3135945 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TREX1 gene
The following variants in TREX1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3135945 variant in the TREX1 gene?
rs3135945 is a single nucleotide polymorphism (SNP) located in the TREX1 (Three Prime Repair Exonuclease 1) gene, which is involved in cytosolic DNA clearance / cGAS-STING regulation. TREX1 is a cytosolic 3'-to-5' exonuclease that degrades cytosolic DNA, preventing spontaneous activation of the cGAS-STING pathway.
How may the rs3135945 variant relate to Long COVID or ME/CFS?
TREX1 loss-of-function mutations cause Aicardi-Goutières syndrome (a monogenic interferonopathy); common variants may affect basal cGAS-STING activation and contribute to the chronic interferon signature in Long COVID.
Can a consumer DNA test detect the rs3135945 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3135945 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TREX1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]NEJM
- [3]Nature Genetics