rs1556314
Variant in the TRPM2 gene (Transient Receptor Potential Cation Channel Subfamily M Member 2)
rs1556314 is a single nucleotide polymorphism (SNP) in the TRPM2 gene, involved in oxidative stress / ADPR calcium signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1556314 variant?
rs1556314 is a SNP (single nucleotide polymorphism) in the TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. TRPM2 encodes a TRP channel activated by ADP-ribose (ADPR) and oxidative stress, mediating calcium influx and neuronal and immune cell death.
Biological role and pathway
This variant sits within the TRPM2 gene, which is involved in the oxidative stress / ADPR calcium signaling pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1556314 and Long COVID / ME-CFS research
TRPM2 activation by oxidative stress and ADPR (generated by CD38 via NAD+) may contribute to neuronal damage and fatigue in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TRPM2
rs1556314 is one of 1 known variant in the TRPM2 gene. To understand the full biological context of this variant, explore the parent gene page.
View TRPM2 gene page →Conditions studied in relation to rs1556314
Research into TRPM2 variants including rs1556314 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRPM2 and the rs1556314 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1556314 variant in the TRPM2 gene?
rs1556314 is a single nucleotide polymorphism (SNP) located in the TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) gene, which is involved in oxidative stress / ADPR calcium signaling. TRPM2 encodes a TRP channel activated by ADP-ribose (ADPR) and oxidative stress, mediating calcium influx and neuronal and immune cell death.
How may the rs1556314 variant relate to Long COVID or ME/CFS?
TRPM2 activation by oxidative stress and ADPR (generated by CD38 via NAD+) may contribute to neuronal damage and fatigue in Long COVID.
Can a consumer DNA test detect the rs1556314 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1556314 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TRPM2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Journal of Neuroscience