rs1800849

What is the rs1800849 variant?

rs1800849 is a SNP (single nucleotide polymorphism) in the UCP3 (Uncoupling Protein 3) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. UCP3 is expressed predominantly in skeletal muscle and regulates mitochondrial proton leak and fatty acid metabolism.

Biological role and pathway

This variant sits within the UCP3 gene, which is involved in the mitochondrial uncoupling pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: UCP3

rs1800849 is one of 1 known variant in the UCP3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1800849

Research into UCP3 variants including rs1800849 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include UCP3 and the rs1800849 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions