rs2076463

What is the rs2076463 variant?

rs2076463 is a SNP (single nucleotide polymorphism) in the USP18 (Ubiquitin Specific Peptidase 18) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. USP18 is a critical negative regulator of type I interferon signaling that cleaves ISG15 from proteins and suppresses the IFNAR2 receptor.

Biological role and pathway

This variant sits within the USP18 gene, which is involved in the ISG15/interferon negative regulation pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: USP18

rs2076463 is one of 3 known variants in the USP18 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2076463

Research into USP18 variants including rs2076463 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include USP18 and the rs2076463 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the USP18 gene

The following variants in USP18 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions