rs1544410
Variant in the VDR gene (Vitamin D Receptor)
rs1544410 is a single nucleotide polymorphism (SNP) in the VDR gene, involved in vitamin D / nuclear receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1544410 variant?
rs1544410 is a SNP (single nucleotide polymorphism) in the VDR (Vitamin D Receptor) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. VDR encodes the nuclear receptor for 1,25-dihydroxyvitamin D3, mediating transcriptional effects of vitamin D on immune function, calcium homeostasis, and cellular proliferation.
Biological role and pathway
This variant sits within the VDR gene, which is involved in the vitamin D / nuclear receptor signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1544410 and Long COVID / ME-CFS research
Vitamin D deficiency is strongly associated with severe COVID-19 and Long COVID; VDR variants (BsmI, FokI, ApaI, TaqI) may affect vitamin D responsiveness and immune regulation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: VDR
rs1544410 is one of 4 known variants in the VDR gene. To understand the full biological context of this variant, explore the parent gene page.
View VDR gene page →Conditions studied in relation to rs1544410
Research into VDR variants including rs1544410 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include VDR and the rs1544410 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the VDR gene
The following variants in VDR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1544410 variant in the VDR gene?
rs1544410 is a single nucleotide polymorphism (SNP) located in the VDR (Vitamin D Receptor) gene, which is involved in vitamin D / nuclear receptor signaling. VDR encodes the nuclear receptor for 1,25-dihydroxyvitamin D3, mediating transcriptional effects of vitamin D on immune function, calcium homeostasis, and cellular proliferation.
How may the rs1544410 variant relate to Long COVID or ME/CFS?
Vitamin D deficiency is strongly associated with severe COVID-19 and Long COVID; VDR variants (BsmI, FokI, ApaI, TaqI) may affect vitamin D responsiveness and immune regulation.
Can a consumer DNA test detect the rs1544410 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1544410 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for VDR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33387997
- [2]Nature Reviews Immunology
- [3]Journal of Clinical Investigation