rs25487
Variant in the XRCC1 gene (X-Ray Repair Cross Complementing 1)
rs25487 is a single nucleotide polymorphism (SNP) in the XRCC1 gene, involved in base excision repair. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs25487 variant?
rs25487 is a SNP (single nucleotide polymorphism) in the XRCC1 (X-Ray Repair Cross Complementing 1) gene. It belongs to the Genome Stability category and is part of the Oxidative Stress biological cluster. XRCC1 encodes a scaffold protein coordinating base excision repair (BER) of oxidatively damaged DNA.
Biological role and pathway
This variant sits within the XRCC1 gene, which is involved in the base excision repair pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs25487 and Long COVID / ME-CFS research
Oxidative DNA damage accumulates in Long COVID; XRCC1 variants (especially Arg399Gln) may affect DNA repair efficiency and contribute to cellular dysfunction in affected tissues.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: XRCC1
rs25487 is one of 3 known variants in the XRCC1 gene. To understand the full biological context of this variant, explore the parent gene page.
View XRCC1 gene page →Conditions studied in relation to rs25487
Research into XRCC1 variants including rs25487 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include XRCC1 and the rs25487 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the XRCC1 gene
The following variants in XRCC1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs25487 variant in the XRCC1 gene?
rs25487 is a single nucleotide polymorphism (SNP) located in the XRCC1 (X-Ray Repair Cross Complementing 1) gene, which is involved in base excision repair. XRCC1 encodes a scaffold protein coordinating base excision repair (BER) of oxidatively damaged DNA.
How may the rs25487 variant relate to Long COVID or ME/CFS?
Oxidative DNA damage accumulates in Long COVID; XRCC1 variants (especially Arg399Gln) may affect DNA repair efficiency and contribute to cellular dysfunction in affected tissues.
Can a consumer DNA test detect the rs25487 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs25487 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for XRCC1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Carcinogenesis
- [3]DNA Repair