rs3178013
Variant in the ZAP70 gene (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70)
rs3178013 is a single nucleotide polymorphism (SNP) in the ZAP70 gene, involved in T cell receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3178013 variant?
rs3178013 is a SNP (single nucleotide polymorphism) in the ZAP70 (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. ZAP70 encodes a kinase recruited to TCR-CD3ζ that propagates T cell activation signals.
Biological role and pathway
This variant sits within the ZAP70 gene, which is involved in the T cell receptor signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3178013 and Long COVID / ME-CFS research
ZAP70 is essential for TCR signal transduction; variants may affect T cell activation thresholds and effector function relevant to antiviral immunity in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ZAP70
rs3178013 is one of 2 known variants in the ZAP70 gene. To understand the full biological context of this variant, explore the parent gene page.
View ZAP70 gene page →Conditions studied in relation to rs3178013
Research into ZAP70 variants including rs3178013 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ZAP70 and the rs3178013 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ZAP70 gene
The following variants in ZAP70 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3178013 variant in the ZAP70 gene?
rs3178013 is a single nucleotide polymorphism (SNP) located in the ZAP70 (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70) gene, which is involved in T cell receptor signaling. ZAP70 encodes a kinase recruited to TCR-CD3ζ that propagates T cell activation signals.
How may the rs3178013 variant relate to Long COVID or ME/CFS?
ZAP70 is essential for TCR signal transduction; variants may affect T cell activation thresholds and effector function relevant to antiviral immunity in Long COVID.
Can a consumer DNA test detect the rs3178013 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3178013 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ZAP70 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Experimental Medicine