rs61731978
Variant in the ZAP70 gene (Zeta Chain of T Cell Receptor Associated Protein Kinase 70)
rs61731978 is a single nucleotide polymorphism (SNP) in the ZAP70 gene, involved in T cell receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs61731978 variant?
rs61731978 is a SNP (single nucleotide polymorphism) in the ZAP70 (Zeta Chain of T Cell Receptor Associated Protein Kinase 70) gene. It belongs to the Lymphocyte category and is part of the Lymphocyte Biology biological cluster. ZAP70 encodes a tyrosine kinase essential for TCR signal transduction, linking CD3 zeta phosphorylation to downstream T cell activation.
Biological role and pathway
This variant sits within the ZAP70 gene, which is involved in the T cell receptor signaling pathway. Genes within the Lymphocyte Biology cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs61731978 and Long COVID / ME-CFS research
ZAP70 function influences T cell activation thresholds and may affect the quality of anti-SARS-CoV-2 T cell responses in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ZAP70
rs61731978 is one of 2 known variants in the ZAP70 gene. To understand the full biological context of this variant, explore the parent gene page.
View ZAP70 gene page →Conditions studied in relation to rs61731978
Research into ZAP70 variants including rs61731978 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ZAP70 and the rs61731978 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ZAP70 gene
The following variants in ZAP70 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs61731978 variant in the ZAP70 gene?
rs61731978 is a single nucleotide polymorphism (SNP) located in the ZAP70 (Zeta Chain of T Cell Receptor Associated Protein Kinase 70) gene, which is involved in T cell receptor signaling. ZAP70 encodes a tyrosine kinase essential for TCR signal transduction, linking CD3 zeta phosphorylation to downstream T cell activation.
How may the rs61731978 variant relate to Long COVID or ME/CFS?
ZAP70 function influences T cell activation thresholds and may affect the quality of anti-SARS-CoV-2 T cell responses in Long COVID.
Can a consumer DNA test detect the rs61731978 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs61731978 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ZAP70 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation