rs13107325

What is the rs13107325 variant?

rs13107325 is a SNP (single nucleotide polymorphism) in the SLC39A8 (Solute Carrier Family 39 Member 8 (ZIP8)) gene. It belongs to the Metabolic category and is part of the Oxidative Stress biological cluster. SLC39A8 encodes ZIP8, a zinc and manganese transporter; rs13107325 (Ala391Thr) affects manganese import for MnSOD (SOD2) and other manganoenzymes.

Biological role and pathway

This variant sits within the SLC39A8 gene, which is involved in the zinc and manganese import / MnSOD cofactor pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SLC39A8

rs13107325 is one of 2 known variants in the SLC39A8 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs13107325

Research into SLC39A8 variants including rs13107325 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC39A8 and the rs13107325 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the SLC39A8 gene

The following variants in SLC39A8 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions