POLG Gene

What is the POLG gene?

POLG encodes dna polymerase gamma catalytic subunit, a protein involved in mitochondrial DNA replication. It belongs to the Genome Stability category and is part of the Mitochondrial Energy Production & PEM biological cluster. POLG encodes the catalytic subunit of mitochondrial DNA polymerase gamma, responsible for mtDNA replication and repair.

Biological role and pathway

POLG is involved in the mitochondrial DNA replication pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the POLG gene have been studied in relation to genome stability and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs3087374— POLG variant
• rs2307441— POLG variant

Conditions studied in relation to POLG

Research into POLG variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that POLG causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include POLG and related genes in the mitochondrial energy production & pem pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Mitochondrial Energy Production & PEM pathway

POLG does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions