rs3087374

What is the rs3087374 variant?

rs3087374 is a SNP (single nucleotide polymorphism) in the POLG (DNA Polymerase Gamma Catalytic Subunit) gene. It belongs to the Genome Stability category and is part of the Mitochondrial Energy Production & PEM biological cluster. POLG encodes the catalytic subunit of mitochondrial DNA polymerase gamma, responsible for mtDNA replication and repair.

Biological role and pathway

This variant sits within the POLG gene, which is involved in the mitochondrial DNA replication pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: POLG

rs3087374 is one of 2 known variants in the POLG gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3087374

Research into POLG variants including rs3087374 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include POLG and the rs3087374 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the POLG gene

The following variants in POLG are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions