rs2307441
Variant in the POLG gene (DNA Polymerase Gamma Catalytic Subunit)
rs2307441 is a single nucleotide polymorphism (SNP) in the POLG gene, involved in mitochondrial DNA replication. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2307441 variant?
rs2307441 is a SNP (single nucleotide polymorphism) in the POLG (DNA Polymerase Gamma Catalytic Subunit) gene. It belongs to the Genome Stability category and is part of the Mitochondrial Energy Production & PEM biological cluster. POLG encodes the catalytic subunit of mitochondrial DNA polymerase gamma, responsible for mtDNA replication and repair.
Biological role and pathway
This variant sits within the POLG gene, which is involved in the mitochondrial DNA replication pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2307441 and Long COVID / ME-CFS research
POLG variants affecting mtDNA replication fidelity may lead to mtDNA depletion or mutations, impairing mitochondrial function and contributing to fatigue in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: POLG
rs2307441 is one of 2 known variants in the POLG gene. To understand the full biological context of this variant, explore the parent gene page.
View POLG gene page →Conditions studied in relation to rs2307441
Research into POLG variants including rs2307441 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include POLG and the rs2307441 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the POLG gene
The following variants in POLG are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2307441 variant in the POLG gene?
rs2307441 is a single nucleotide polymorphism (SNP) located in the POLG (DNA Polymerase Gamma Catalytic Subunit) gene, which is involved in mitochondrial DNA replication. POLG encodes the catalytic subunit of mitochondrial DNA polymerase gamma, responsible for mtDNA replication and repair.
How may the rs2307441 variant relate to Long COVID or ME/CFS?
POLG variants affecting mtDNA replication fidelity may lead to mtDNA depletion or mutations, impairing mitochondrial function and contributing to fatigue in Long COVID.
Can a consumer DNA test detect the rs2307441 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2307441 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for POLG and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]AJHG