rs3759129

What is the rs3759129 variant?

rs3759129 is a SNP (single nucleotide polymorphism) in the AVP (Arginine Vasopressin (Antidiuretic Hormone)) gene. It belongs to the Neuroendocrine category and is part of the Autonomic Nervous System biological cluster. AVP encodes arginine vasopressin (ADH), which regulates water reabsorption in the kidney and modulates the HPA axis stress response.

Biological role and pathway

This variant sits within the AVP gene, which is involved in the fluid balance / HPA axis modulation pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: AVP

rs3759129 is one of 2 known variants in the AVP gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3759129

Research into AVP variants including rs3759129 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AVP and the rs3759129 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the AVP gene

The following variants in AVP are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions

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