rs4732625
Variant in the AVP gene (Arginine Vasopressin)
rs4732625 is a single nucleotide polymorphism (SNP) in the AVP gene, involved in fluid homeostasis and HPA axis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4732625 variant?
rs4732625 is a SNP (single nucleotide polymorphism) in the AVP (Arginine Vasopressin) gene. It belongs to the Autonomic category and is part of the HPA Axis & Stress Response biological cluster. AVP encodes arginine vasopressin (antidiuretic hormone), which regulates fluid balance, vasoconstriction, and HPA axis activation.
Biological role and pathway
This variant sits within the AVP gene, which is involved in the fluid homeostasis and HPA axis pathway. Genes within the HPA Axis & Stress Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4732625 and Long COVID / ME-CFS research
AVP dysregulation may contribute to fluid balance abnormalities, autonomic instability, and HPA axis dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: AVP
rs4732625 is one of 2 known variants in the AVP gene. To understand the full biological context of this variant, explore the parent gene page.
View AVP gene page →Conditions studied in relation to rs4732625
Research into AVP variants including rs4732625 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AVP and the rs4732625 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the AVP gene
The following variants in AVP are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4732625 variant in the AVP gene?
rs4732625 is a single nucleotide polymorphism (SNP) located in the AVP (Arginine Vasopressin) gene, which is involved in fluid homeostasis and HPA axis. AVP encodes arginine vasopressin (antidiuretic hormone), which regulates fluid balance, vasoconstriction, and HPA axis activation.
How may the rs4732625 variant relate to Long COVID or ME/CFS?
AVP dysregulation may contribute to fluid balance abnormalities, autonomic instability, and HPA axis dysfunction in Long COVID.
Can a consumer DNA test detect the rs4732625 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Related articles
- Long COVID Dysautonomia: What Your Genes May Reveal
Explore how genes in the autonomic nervous system may relate to Long COVID dysautonomia, including POTS, heart rate changes and orthostatic intolerance.
- Long COVID POTS: Symptoms, Testing and Genetics
Learn how Long COVID POTS affects heart rate, how standing and tilt table tests assess it, and which genes research is exploring.
Find out if you carry the rs4732625 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for AVP and its variants. This is not an exhaustive literature review.
- [1]PMID: 33948838
- [2]Nature Genetics
- [3]Journal of Clinical Investigation