rs2270363
Variant in the HMOX2 gene (Heme Oxygenase 2)
rs2270363 is a single nucleotide polymorphism (SNP) in the HMOX2 gene, involved in heme catabolism / constitutive. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2270363 variant?
rs2270363 is a SNP (single nucleotide polymorphism) in the HMOX2 (Heme Oxygenase 2) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. HMOX2 encodes heme oxygenase 2, the constitutively expressed isoform that catabolizes heme to biliverdin and carbon monoxide.
Biological role and pathway
This variant sits within the HMOX2 gene, which is involved in the heme catabolism / constitutive pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2270363 and Long COVID / ME-CFS research
HMOX2 provides baseline heme clearance and CO-mediated cytoprotection; variants may affect constitutive heme metabolism and antioxidant protection relevant to Long COVID hemolytic and inflammatory stress.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HMOX2
rs2270363 is one of 1 known variant in the HMOX2 gene. To understand the full biological context of this variant, explore the parent gene page.
View HMOX2 gene page →Conditions studied in relation to rs2270363
Research into HMOX2 variants including rs2270363 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HMOX2 and the rs2270363 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HMOX2 gene
The following variants in HMOX2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2270363 variant in the HMOX2 gene?
rs2270363 is a single nucleotide polymorphism (SNP) located in the HMOX2 (Heme Oxygenase 2) gene, which is involved in heme catabolism / constitutive. HMOX2 encodes heme oxygenase 2, the constitutively expressed isoform that catabolizes heme to biliverdin and carbon monoxide.
How may the rs2270363 variant relate to Long COVID or ME/CFS?
HMOX2 provides baseline heme clearance and CO-mediated cytoprotection; variants may affect constitutive heme metabolism and antioxidant protection relevant to Long COVID hemolytic and inflammatory stress.
Can a consumer DNA test detect the rs2270363 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2270363 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for HMOX2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Nature Genetics
- [3]Antioxidants and Redox Signaling