rs4786504

What is the rs4786504 variant?

rs4786504 is a SNP (single nucleotide polymorphism) in the HMOX2 (Heme Oxygenase 2) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. HMOX2 encodes the constitutively expressed heme oxygenase isoform that provides baseline cytoprotection in neurons and other tissues.

Biological role and pathway

This variant sits within the HMOX2 gene, which is involved in the constitutive heme catabolism pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HMOX2

rs4786504 is one of 1 known variant in the HMOX2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4786504

Research into HMOX2 variants including rs4786504 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HMOX2 and the rs4786504 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HMOX2 gene

The following variants in HMOX2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions