rs1159011
Variant in the PECAM1 gene (Platelet And Endothelial Cell Adhesion Molecule 1 (CD31))
rs1159011 is a single nucleotide polymorphism (SNP) in the PECAM1 gene, involved in endothelial cell adhesion / platelet function. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1159011 variant?
rs1159011 is a SNP (single nucleotide polymorphism) in the PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1 (CD31)) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. PECAM1 encodes CD31, an adhesion molecule on endothelial cells, platelets, and leukocytes involved in vascular integrity and immune cell transmigration.
Biological role and pathway
This variant sits within the PECAM1 gene, which is involved in the endothelial cell adhesion / platelet function pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1159011 and Long COVID / ME-CFS research
PECAM1 facilitates leukocyte migration across endothelium; variants may affect inflammatory cell infiltration of tissues and vascular inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PECAM1
rs1159011 is one of 3 known variants in the PECAM1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PECAM1 gene page →Conditions studied in relation to rs1159011
Research into PECAM1 variants including rs1159011 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PECAM1 and the rs1159011 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PECAM1 gene
The following variants in PECAM1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1159011 variant in the PECAM1 gene?
rs1159011 is a single nucleotide polymorphism (SNP) located in the PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1 (CD31)) gene, which is involved in endothelial cell adhesion / platelet function. PECAM1 encodes CD31, an adhesion molecule on endothelial cells, platelets, and leukocytes involved in vascular integrity and immune cell transmigration.
How may the rs1159011 variant relate to Long COVID or ME/CFS?
PECAM1 facilitates leukocyte migration across endothelium; variants may affect inflammatory cell infiltration of tissues and vascular inflammation in Long COVID.
Can a consumer DNA test detect the rs1159011 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1159011 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PECAM1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Arteriosclerosis Thrombosis and Vascular Biology