rs11099293
Variant in the PROS1 gene (Protein S)
rs11099293 is a single nucleotide polymorphism (SNP) in the PROS1 gene, involved in anticoagulation cofactor. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11099293 variant?
rs11099293 is a SNP (single nucleotide polymorphism) in the PROS1 (Protein S) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. PROS1 encodes protein S, a vitamin K-dependent anticoagulant that acts as a cofactor for activated protein C.
Biological role and pathway
This variant sits within the PROS1 gene, which is involved in the anticoagulation cofactor pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11099293 and Long COVID / ME-CFS research
Protein S deficiency increases thrombotic risk; antiphospholipid antibodies in COVID-19 can impair protein S function, contributing to thrombosis in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PROS1
rs11099293 is one of 3 known variants in the PROS1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PROS1 gene page →Conditions studied in relation to rs11099293
Research into PROS1 variants including rs11099293 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PROS1 and the rs11099293 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PROS1 gene
The following variants in PROS1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11099293 variant in the PROS1 gene?
rs11099293 is a single nucleotide polymorphism (SNP) located in the PROS1 (Protein S) gene, which is involved in anticoagulation cofactor. PROS1 encodes protein S, a vitamin K-dependent anticoagulant that acts as a cofactor for activated protein C.
How may the rs11099293 variant relate to Long COVID or ME/CFS?
Protein S deficiency increases thrombotic risk; antiphospholipid antibodies in COVID-19 can impair protein S function, contributing to thrombosis in Long COVID patients.
Can a consumer DNA test detect the rs11099293 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11099293 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PROS1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Blood