rs9178819

What is the rs9178819 variant?

rs9178819 is a SNP (single nucleotide polymorphism) in the PROS1 (Protein S) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. PROS1 encodes protein S, a vitamin K-dependent cofactor for activated protein C that inactivates coagulation factors Va and VIIIa.

Biological role and pathway

This variant sits within the PROS1 gene, which is involved in the anticoagulation pathway pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: PROS1

rs9178819 is one of 3 known variants in the PROS1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs9178819

Research into PROS1 variants including rs9178819 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PROS1 and the rs9178819 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the PROS1 gene

The following variants in PROS1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions