rs15904
Variant in the PROS1 gene (Protein S1)
rs15904 is a single nucleotide polymorphism (SNP) in the PROS1 gene, involved in anticoagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs15904 variant?
rs15904 is a SNP (single nucleotide polymorphism) in the PROS1 (Protein S1) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. Protein S is the vitamin K-dependent cofactor for activated protein C (APC). Free protein S enhances APC inactivation of factors Va and VIIIa and independently inhibits factor Xa; deficiency causes recurrent venous thromboembolism.
Biological role and pathway
This variant sits within the PROS1 gene, which is involved in the anticoagulation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs15904 and Long COVID / ME-CFS research
Free protein S levels are reduced in COVID-19 due to acute phase increases in C4b-binding protein. Protein S deficiency with PROS1 variants may compound COVID-19-associated hypercoagulability, increasing risk of Long COVID vascular thrombosis.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: PROS1
rs15904 is one of 3 known variants in the PROS1 gene. To understand the full biological context of this variant, explore the parent gene page.
View PROS1 gene page →Conditions studied in relation to rs15904
Research into PROS1 variants including rs15904 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include PROS1 and the rs15904 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the PROS1 gene
The following variants in PROS1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs15904 variant in the PROS1 gene?
rs15904 is a single nucleotide polymorphism (SNP) located in the PROS1 (Protein S1) gene, which is involved in anticoagulation. Protein S is the vitamin K-dependent cofactor for activated protein C (APC). Free protein S enhances APC inactivation of factors Va and VIIIa and independently inhibits factor Xa; deficiency causes recurrent venous thromboembolism.
How may the rs15904 variant relate to Long COVID or ME/CFS?
Free protein S levels are reduced in COVID-19 due to acute phase increases in C4b-binding protein. Protein S deficiency with PROS1 variants may compound COVID-19-associated hypercoagulability, increasing risk of Long COVID vascular thrombosis.
Can a consumer DNA test detect the rs15904 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs15904 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for PROS1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29728449
- [2]Blood
- [3]Thrombosis and Haemostasis