rs143340306

What is the rs143340306 variant?

rs143340306 is a SNP (single nucleotide polymorphism) in the SERPING1 (Serpin Family G Member 1 (C1-Inhibitor)) gene. It belongs to the Immune Signaling category and is part of the Coagulation & Microcirculation biological cluster. SERPING1 encodes C1-inhibitor, which inhibits C1r and C1s to prevent spontaneous complement activation, and also inhibits plasma kallikrein and factor XIIa.

Biological role and pathway

This variant sits within the SERPING1 gene, which is involved in the classical complement and contact system inhibition pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SERPING1

rs143340306 is one of 3 known variants in the SERPING1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs143340306

Research into SERPING1 variants including rs143340306 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SERPING1 and the rs143340306 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the SERPING1 gene

The following variants in SERPING1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions