rs11555236

What is the rs11555236 variant?

rs11555236 is a SNP (single nucleotide polymorphism) in the SIRT3 (Sirtuin 3 (Mitochondrial)) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. SIRT3 is the primary mitochondrial sirtuin that deacetylates and activates mitochondrial metabolic enzymes in response to NAD+.

Biological role and pathway

This variant sits within the SIRT3 gene, which is involved in the mitochondrial protein deacetylation / energy regulation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SIRT3

rs11555236 is one of 3 known variants in the SIRT3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs11555236

Research into SIRT3 variants including rs11555236 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SIRT3 and the rs11555236 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the SIRT3 gene

The following variants in SIRT3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions