rs11246020
Variant in the SIRT3 gene (Sirtuin 3)
rs11246020 is a single nucleotide polymorphism (SNP) in the SIRT3 gene, involved in mitochondrial protein deacetylation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11246020 variant?
rs11246020 is a SNP (single nucleotide polymorphism) in the SIRT3 (Sirtuin 3) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. SIRT3 encodes the primary mitochondrial deacetylase that regulates metabolic enzymes and antioxidant defenses.
Biological role and pathway
This variant sits within the SIRT3 gene, which is involved in the mitochondrial protein deacetylation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11246020 and Long COVID / ME-CFS research
SIRT3 coordinates mitochondrial function and oxidative stress responses; impaired SIRT3 activity may worsen mitochondrial dysfunction in Long COVID fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SIRT3
rs11246020 is one of 3 known variants in the SIRT3 gene. To understand the full biological context of this variant, explore the parent gene page.
View SIRT3 gene page →Conditions studied in relation to rs11246020
Research into SIRT3 variants including rs11246020 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SIRT3 and the rs11246020 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SIRT3 gene
The following variants in SIRT3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11246020 variant in the SIRT3 gene?
rs11246020 is a single nucleotide polymorphism (SNP) located in the SIRT3 (Sirtuin 3) gene, which is involved in mitochondrial protein deacetylation. SIRT3 encodes the primary mitochondrial deacetylase that regulates metabolic enzymes and antioxidant defenses.
How may the rs11246020 variant relate to Long COVID or ME/CFS?
SIRT3 coordinates mitochondrial function and oxidative stress responses; impaired SIRT3 activity may worsen mitochondrial dysfunction in Long COVID fatigue.
Can a consumer DNA test detect the rs11246020 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11246020 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SIRT3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation