rs4980329
Variant in the SIRT3 gene (Sirtuin 3)
rs4980329 is a single nucleotide polymorphism (SNP) in the SIRT3 gene, involved in mitochondrial regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4980329 variant?
rs4980329 is a SNP (single nucleotide polymorphism) in the SIRT3 (Sirtuin 3) gene. It belongs to the Metabolism category and is part of the Mitochondrial & Metabolic biological cluster. SIRT3 is the primary mitochondrial deacetylase, regulating oxidative phosphorylation, antioxidant defenses, and fatty acid oxidation. It deacetylates numerous mitochondrial proteins to maintain bioenergetic efficiency.
Biological role and pathway
This variant sits within the SIRT3 gene, which is involved in the mitochondrial regulation pathway. Genes within the Mitochondrial & Metabolic cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4980329 and Long COVID / ME-CFS research
Mitochondrial dysfunction is a key mechanism in ME/CFS and Long COVID. SIRT3 polymorphisms affecting mitochondrial protein deacetylation may impair energy production and increase oxidative stress in affected tissues.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SIRT3
rs4980329 is one of 3 known variants in the SIRT3 gene. To understand the full biological context of this variant, explore the parent gene page.
View SIRT3 gene page →Conditions studied in relation to rs4980329
Research into SIRT3 variants including rs4980329 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SIRT3 and the rs4980329 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SIRT3 gene
The following variants in SIRT3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4980329 variant in the SIRT3 gene?
rs4980329 is a single nucleotide polymorphism (SNP) located in the SIRT3 (Sirtuin 3) gene, which is involved in mitochondrial regulation. SIRT3 is the primary mitochondrial deacetylase, regulating oxidative phosphorylation, antioxidant defenses, and fatty acid oxidation. It deacetylates numerous mitochondrial proteins to maintain bioenergetic efficiency.
How may the rs4980329 variant relate to Long COVID or ME/CFS?
Mitochondrial dysfunction is a key mechanism in ME/CFS and Long COVID. SIRT3 polymorphisms affecting mitochondrial protein deacetylation may impair energy production and increase oxidative stress in affected tissues.
Can a consumer DNA test detect the rs4980329 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4980329 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SIRT3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 24508390
- [2]Cell Metabolism
- [3]Nature Chemical Biology