rs11111979
Variant in the TXNRD1 gene (Thioredoxin Reductase 1)
rs11111979 is a single nucleotide polymorphism (SNP) in the TXNRD1 gene, involved in thioredoxin antioxidant system. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11111979 variant?
rs11111979 is a SNP (single nucleotide polymorphism) in the TXNRD1 (Thioredoxin Reductase 1) gene. It belongs to the Oxidative Stress category and is part of the Oxidative Stress biological cluster. TXNRD1 encodes cytoplasmic thioredoxin reductase, a selenoprotein that regenerates reduced thioredoxin to maintain cellular redox homeostasis.
Biological role and pathway
This variant sits within the TXNRD1 gene, which is involved in the thioredoxin antioxidant system pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11111979 and Long COVID / ME-CFS research
TXNRD1 variants may reduce thioredoxin antioxidant capacity and increase susceptibility to oxidative stress in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TXNRD1
rs11111979 is one of 1 known variant in the TXNRD1 gene. To understand the full biological context of this variant, explore the parent gene page.
View TXNRD1 gene page →Conditions studied in relation to rs11111979
Research into TXNRD1 variants including rs11111979 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TXNRD1 and the rs11111979 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TXNRD1 gene
The following variants in TXNRD1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11111979 variant in the TXNRD1 gene?
rs11111979 is a single nucleotide polymorphism (SNP) located in the TXNRD1 (Thioredoxin Reductase 1) gene, which is involved in thioredoxin antioxidant system. TXNRD1 encodes cytoplasmic thioredoxin reductase, a selenoprotein that regenerates reduced thioredoxin to maintain cellular redox homeostasis.
How may the rs11111979 variant relate to Long COVID or ME/CFS?
TXNRD1 variants may reduce thioredoxin antioxidant capacity and increase susceptibility to oxidative stress in Long COVID.
Can a consumer DNA test detect the rs11111979 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11111979 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TXNRD1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25122754
- [2]Nature Genetics
- [3]Journal of Clinical Investigation